羧(suo)甲(jia)(jia)淀(dian)(dian)(dian)(dian)(dian)(dian)粉钠(na)(na)(na)(na)是淀(dian)(dian)(dian)(dian)(dian)(dian)粉在碱(jian)(jian)性(xing)条件(jian)下与氯乙酸作用(yong)生成的淀(dian)(dian)(dian)(dian)(dian)(dian)粉羧(suo)甲(jia)(jia)基(ji)醚(mi)的钠(na)(na)(na)(na)盐。通过对羧(suo)甲(jia)(jia)淀(dian)(dian)(dian)(dian)(dian)(dian)粉钠(na)(na)(na)(na)合成工艺路(lu)线的文献检索及(ji)比较，结合本公司的实际(ji)，最终确(que)定合成路(lu)线如下：以淀(dian)(dian)(dian)(dian)(dian)(dian)粉为原料，在碱(jian)(jian)性(xing)条件(jian)下与氯乙酸进行醚(mi)化反应，生成淀(dian)(dian)(dian)(dian)(dian)(dian)粉羧(suo)甲(jia)(jia)基(ji)醚(mi)的钠(na)(na)(na)(na)盐，即羧(suo)甲(jia)(jia)淀(dian)(dian)(dian)(dian)(dian)(dian)粉钠(na)(na)(na)(na)。本法制得羧(suo)甲(jia)(jia)淀(dian)(dian)(dian)(dian)(dian)(dian)粉钠(na)(na)(na)(na)符合药典要求，有很强的吸水膨(peng)胀性(xing),促进药物的溶出速度,大大提高了药物的生物利用度。